Fifth Avenue is a major thoroughfare in the center of the boroughs of Manhattan and the Bronx in New York City, USA. It runs through the heart of Midtown and along the eastern side of Central Park, and because of the expensive park-view real estate and historical mansions along its course, it is a symbol of wealthy New York. It is the dividing line for the east-west streets in Manhattan and the Bronx, (for example, demarcating the line separating East 59th Street from West 59th Street) as well as the zero-numbering point for street addresses (numbers increase in both directions as one moves away from Fifth, with 1 East 59th Street on the corner at Fifth Avenue, and 300 East 59th Street located several blocks to the East).

Fifth Avenue is a one-way street and carries southbound ("downtown") traffic. Some people refer to Fifth Avenue colloquially as "Fashion Ave," but many refrain from it to avoid confusion with the real Fashion Ave, also known as Seventh Avenue.